The game description on WiiWare claims that Dr. Mario RX Online for the Wii is for up to 4 players. Now, technically, 4 players can play cooperatively in the VirusBuster version of the game, but you can play 2-player only for the classic mode, which is the real reason to play the game. This is a step back from the N64 version, and not cool. The online play is fun, but the waiting time can be unreasonable, and they should give you something to look at or do while waiting. Overall, I’d say it’s worth about half as much as you pay for it…

Source: Wii

PS – RX is shorthand for prescription.